Nonclinical Services

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Development Service of Regenerative medicine Products

Efficacy Evaluation

Efficacy Evaluation Liver Fibrosis Circulatory Organ / Peripheral Arterial Disease Central Nervous System Voiding Function Cancer Autoimmune Disease

Liver Fibrosis

Hepatitis
  • Non-alcoholic steatohepatitis (NASH) model
  • Carbon tetrachloride-induced hepatitis
Hepatitis

Circulatory Organ / Peripheral Arterial Disease

Cardiac disease
  • Cardiac infarction (ishcemia-reperfusion) model
Cardiac disease
Abdominal aortic aneurysm
  • Calcium chloride-induced abdominal aortic aneurysm model
Abdominal aortic aneurysm
Peripheral arterial disease (PAD)
  • Hind limb ischemia model
Peripheral arterial disease (PAD)

Central Nervous System

Cerebral ischaemia
  • Transient middle cerebral (MCA) artery occlusion
Depression / epilepsy
  • Forced swimming test (depression)
  • Tail suspension test (depression)
  • Kainic acid-induced (epileps)
Depression / Epilepsy
Learning and memory impairment
  • Alzheimer's disease (AD)
  • Scopolamine-induced amnesia
  • Lesions of the nucleus basalis of Meynert
Learning and memory impairment

Voiding Function

Overactive bladder model
Lower urinary tract symptoms
(LUTS: benign prostatic hyperplasia [BPH])
Spinal cord injury, stress urinary incontinence
(SUI)
  • Cystometry
  • Uroflowmetry
Overactive bladder model, Lower urinary tract symptoms (LUTS: benign prostatic hyperplasia [BPH]), Spinal cord injury, stress urinary incontinence (SUI)
Interstitial cystitis
(IC: hydrochloric acid, cyclophosphamide or acetic acid-induced)
  • Cystometry
  • Uroflowmetry
  • Measurement of spontaneous locomotive activity
  • fMRI

Cancer

Liver cancer
  • Rabbit VX2 cancer transplantation model (only feasible by our company)
Liver cancer
in vivo antitumor study
  • Splenic liver metastasis model (human colon cancer cell line HT-29)
  • Orthotopic implantation model
    • Cervical cancer cell line
    • Prostatic cancer cell line
    • Glioblastoma-derived cell line
  • Subcutaneous implantation model
    • SCID, NOD/SCID, and NOG are available
Cancer pain
  • Bone metastasis model (rat breast cancer cell line MRMT-1)
Cancer pain

Autoimmune Disease

Systemic lupus erythematous (SLE)
  • MRL/lpr mice (spontaneously)
  • NZBWF1 mice (spontaneously)
Systemic lupus erythematous (SLE)
Rheumatoid arthritis (RA)
  • Type II collagen-induced arthritis model
Rheumatoid arthritis (RA)
Multiple Sclerosis
(Experimental autoimmune encephalomyelitis: EAE)
  • Relapse-remission type model (SJL mice)
  • Chronic type model (C57BL mice)
Multiple Sclerosis (Experimental autoimmune encephalomyelitis: EAE)
Colitis
  • Ulcerative colitis (DSS-induced)
  • Crohnfs disease (TNBS-induce)
Colitis

Safety Evaluation

From efficacy evaluation to safety evaluation
From efficacy evaluation to safety evaluation

Approved for Compliance with regenerative medicine GLP

  • Safety Assessment Building
    Safety Assessment Building
  • Array Scan
    Array Scan VTI

    (high-content imaging system)
    Thermo Fisher Scientific K.K.
    Improved conventional method, which led to high sensitivity and accurate detection
    Digital soft agar colony formation assay is now available.

  • Actual working scene using individual ventilation rack used in regenerative medicine related studies
    Actual working scene using individual ventilation rack used in regenerative medicine related studies

    (housing of immunodeficient animals)

  • Biodistribution study Detection of human mesenchymal stem cells (hMSCs) in rats
    Biodistribution study
    Detection of human mesenchymal stem cells (hMSCs) in rats

    Double staining with anti-human lamine antibody and mitochondrial antibody
    (Rat lung tissue, arrow: positive cells)

Immunodeficient animal

Species common name Strain
Rat Nude F344/NJcl-rnu/rnu
Mouse Nude CAnN.Cg-Foxn1nu/CrlCrlj, BALB/cAJcl-nu/nu
SCID CB17/lcr-Prkdcscid/CrlCrlj
NOD/SCID NOD.CB17-Prkdcscid/J
NOG NOD.Cg-Prkdcscid Il2rgtm1Sug/ShiJic
NSG NOD.Cg-Prkdcscid Il2rgtm1lWjl/SzJ

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